Plant Science

Programmes

The Sainsbury Laboratory - Norwich

This Laboratory opened on the campus of the John Innes Centre in 1989 and has established a global reputation in plant and microbial science. The Lab is dedicated to daring, long-term research which will help reduce crop losses to important diseases.

The Sainsbury Laboratory - Norwich

The Sainsbury Laboratory (TSL) is a charitable company of approximately 80 research scientists and support staff and a world leader in plant science. TSL is based on the Norwich Research Park and is closely linked to Gatsby, the University of East Anglia and the John Innes Centre (JIC).

TSL is dedicated to making fundamental discoveries about plants and how they interact with microbes and viruses and favours daring, long-term research over work that could be equally well carried out elsewhere. The Laboratory is recognised as a centre of excellence for research on mechanisms of plant immunity and pathogenicity, and has a budding reputation for its research in plant pathogenomics. Groundbreaking work that has arisen from the Laboratory includes the cloning of the first of the receptor-like protein class of plant resistance genes and the discovery of small interfering RNA (siRNA), the specificity determinant in RNA-mediated gene silencing.

Scientists working within the Laboratory have access to state of the art technologies and support services to enable cutting-edge science; TSL was one of the first research establishments in Europe to have access to next generation sequencing technology. Proteomics research is well supported with access to state of the art mass spectrometers and in-house scientific expertise. Similarly, high throughout cell biology research is possible using confocal high content screening microscopy instrumentation.

The Laboratory provides an outstanding training environment that prepares post-graduate students, post-doctoral scientists and early career project leaders to excel in their careers. Many scientists who have passed through The Laboratory have continued their careers in prestigious laboratories and institutes around the world.

In addition to the fundamental research conducted within the Laboratory, TSL has decided to develop the TSL+ programme which encompasses projects with a more direct applied aspect, in many cases building on discoveries that have arisen from the fundamental work in the lab. In doing this, the Laboratory commits core resources of the lab to projects that aim to reduce crop losses to important diseases. The Two Blades Foundation has a research group established within the Laboratory which focuses solely on work that falls under the TSL+ programme.

The Laboratory seeks to put all its scientific discoveries into the public domain and this is mainly achieved through participation in conferences, and publication of peer-reviewed scientific papers, review articles and popular science features. In 2010 TSL and JIC topped a survey, published by Times Higher Education, ranking the most influential papers of the last ten years in plant and animal sciences.

In June 2013, the Laboratory celebrated its 25th anniversary by hosting an Anniversary Symposium in Norwich for TSL alumni, council members and other associates. A commemorative booklet and a short film were produced (see the box to the right of this page) to reveal the people and personalities behind the Laboratory's discoveries, and to show their perspective on what makes it a unique place to conduct science.

Research leaders

Professor Cyril Zipfel

Head of Laboratory

Receptor kinase-mediated innate immunity in plants

Professor Jonathan Jones

Senior Research Scientist

How plants resist plant pathogens, and how pathogens suppress resistance

Professor Sophien Kamoun

Senior Research Scientist

Plant-microbe interactions particularly those involving oomycete pathosystems

Dr Ksenia Krasileva

Group Leader

Understanding the molecular basis of plant disease resistance in wheat

Dr Matthew Moscou

Group Leader

Understanding the genetic architecture underlying non-host resistance

Dr Silke Robatzek

Group Leader

The role of membrane-bound intracellular compartments in the communication between plants and pathogens

Dr Peter van Esse

2Blades Group Leader

Development and deployment of durable and race-independent resistance against Asian Soybean Rust